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The cells were incubated in 6-well plates (2 mL/well) at a density of 150,000 per well for 24 h, followed by treatment with test compounds with or without cisplatin (1 M) for 48 h

Furthermore, the beneficial effect of glutathione on H 2 O 2 -induced DNA damage was significantly reduced by ZnPP, which also implies that the protective role of glutathione on H 2 O 2 -induced cytotoxicity was dependent on HO-1

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Toraya-Brown S, Fiering S

As expected, Gclc -deficient mice showed lower frequencies of MZP compared to control mice (Fig

This process is known as the Gamma-glutamyl cycle